PC-II and its Commercial Version

At the Physics Research Laboratory, an improved area sensing rotate-translate PET instrument, PC-II, was constructed 1971-1976 and the tomographic images obtained using PC-I and PC-II were widely disseminated at meetings and in publications (Figures 6-14) (Chesler et al 1973, Brownell et al 1974, Chesler and Riederer 1975, Correia et al 1976, Brownell et al 1976, Hoop et al 1976, Brownell and Cochavi 1978, Brownell et al 1983).

PC-I was the first device to obtain PET images and, together with PC-II, remained the only PET devices in use for animal and human imaging for almost a decade. A commercial version developed by The Cyclotron Corporation incorporated additional features (Figure 15). (EMI used an iterative algorithm for reconstruction of data from their original machines.) Among those contributing to the early studies were Saadia Cochavi, Wally Ahluwalia, Barney Hoop, John Correia and Nathaniel Alpert.

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Figure 8: PA and left lateral images (left and center) and transverse section images (right) of 68 Ga infused into dog myocardium using PC-I.

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Figure 9: Top level: A-P anatomical illustration of heart and major vessels (left). Anatomical transverse section at the level shown in left. Lower level: Transverse section image of blood pool using inhalation of 11 CO corresponding the image on top right, uncorrected for absorption (left). Same as left with absorption correction (right).

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Figure 10: 18 F (NaF) bone scan using PC-I. AP view shows multiple bone metastases in the pelvic area, the spine, the ribs, and the calvarium. The figure at the middle shows the levels where tomographic slices were reconstructed. Tomographic slices show better assessment of the location and size of the metastases.

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Figure 11: Brain study using 68 Ga – ATP. Lower panel shows 4 tomographic coronal slices and the arrow points the tumor.

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Figure 12: Brain study of the normal control patient using 18 F  2-fluoro-2-deoxy-D-glucose and PC-II.

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Figure 13: Study of glucose metabolism (18 F 2-fluoro-2-deoxy-D-glucose), blood flow (continuous inhalation of 15 O 2 ), oxygen metabolism (continuous inhalation of C 15 O 2) and oxygen extraction fraction in a rabbit tumor model using PC-II.

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Figure 14: Blood flow study of soft tissue tumor in the left leg using PC-II and continuous inhalation of C 15 O 2. Transverse slices are correlated with corresponding CT images.

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Figure 15: A commercial version of PC-II; The Cyclotron Corporation Positron Camera Model 4200.